ACE Question

Article| July 2023 ACE Question ASA Monitor 2023, Vol. 87, 7. https://doi.org/10.1097/01.ASM.0000945056.15859.90 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Cite Get Permissions Search Site Citation Question. 2023; 87:7 doi: Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Dropdown Menu input auto suggest filter your All ContentAll PublicationsASA Advanced Topics: anesthesiology continuing education (ace) Which of the following immunosuppressive drugs is MOST likely to cause renal dysfunction? Immunosuppressant are used prevent or treat allograft rejection. Most these act during induction phase immunological response, reducing lymphocyte proliferation. Some them also in maintenance phase. There three main groups based on site action: interleukin-2 (IL-2) production action, cytokine gene expression, purine pyrimidine synthesis. Complications chronic immune suppression shown Table. Tacrolimus a macrolide antibiotic with an action very similar that cyclosporine. However, it more potent and has shorter half-life. It blocks calcineurin, leading reduction various transcription factors IL-2 primarily T-helper lymphocytes. can lead toxicity due afferent arteriolar vasoconstriction subsequent glomerular filtration rate (GFR). Decreasing... You do not currently have access this content.